In 1946, an opportunity for the Brothers to set up a second La Salle school in the country came when then Bacolod City Mayor Alfredo Montelibano, Sr. offered to the De La Salle Brothers a 10-hectare lot where the University stands today.

La Salle College - Bacolod opened with 175 male students from Prep to Grade 5, under seven faculty members. The following decade saw the expansion of La Salle from Grade School to College. In 1966, the Doña Corazon Locsin Montelibano Chapel was built and La Salle Bacolod opened its doors to the first batch of female college students. On 5 July 1988, La Salle Bacolod was formally elevated to University status and christened University of St. La Salle. Known for academic excellence, social research dynamism, and active community involvement and service, the University rises to the challenge of the times - the need to exercise the leadership role in the social transformation of Negros through a relevant and Christian education of young men and women.