La Salle Green Hills is a Catholic institution for boys committed to the education of responsible citizens and future leaders.

During the early fifties, the De La Salle Brothers hesitantly acquired a six-hectare lot on Ortigas Avenue in Mandaluyong to relocate the Novitiate from Baguio and to accommodate increasing requests for admission to grade school.

In July 1959, La Salle Green Hills opened its door to two preparatory sections and one section each for grades one and two. On 24 August 1960, La Salle Green Hills, Inc. was registered as non-stock, non-profit corporation with the Securities and Exchange Commission. In August 1964, the high school was established.

La Salle Green Hills High School Department was given a clean 7-year accreditation by PAASCU using Survey form B in 1982, 1987 and 1998, making it the first and only high school institution to receive such recognition.